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Presently, the world over, there only two
medications for male and one medication for female patients of pattern
hair loss which are approved by the US FDA. This approving body has
stringent guidelines through which the drugs are approved only after
sufficient trials. Minoxidil was the first to be approved followed by
Finasteride.
MINOXIDIL
This drug was initially introduced as an oral medication for
hypertension. It was observed that it produced hypertrichosis
(excessive hair). A topical solution was prepared which could achieve
similar benefits.
Minoxidil is applied to the scalp is used to stimulate hair growth in
adult men and women with a certain type of baldness. Despite much
research over 20 years we still have only a limited understanding of
how minoxidil stimulates hair growth. It tends to prolong the growth
phase of the hair follicle and thereby reduces hair fall.
A 5% solution of minoxidil is available and clinical investigators have
reported it to be considerably more effective than the 2% solution in
halting hair loss and stimulating new hair growth in both men and
women. At all formulations, women have been shown to have a better
response than men to topical minoxidil.
Used as directed, 2% minoxidil has been shown to stimulate hair growth
in about 30% of male patients, with a slightly higher rate in females.
The response rate is improved with use of 5% solution.
If hair growth is going to occur with the use of minoxidil, it usually
occurs after the medicine has been used for several months and lasts
only as long as the medicine continues to be used. Hair loss will begin
again within a few months after minoxidil treatment is stopped.
How
should I use this medicine?
Minoxidil solution is for external use on the scalp only. Do not take
by mouth. Follow the directions that come with the product. The hair
and scalp should be dry before you use minoxidil solution. You do not
need to shampoo your hair before each application. Do not use within 30
minutes of bedtime. After applying minoxidil solution, do not use your
hair dryer on the hot or high setting to dry hair. Also, do not swim or
exercise for 2 hours after using minoxidil solution. Do not use more
often than specified in the directions.
Minoxidil solution must be used on a regular basis for your hair to
regrow. It may take 2—4 months of regular use before you notice any
improvement. It is important to continue to use minoxidil solution to
maintain regrowth of hair. Once you stop using minoxidil solution, the
regrown hair will usually fall out within 3 months.
Side
effects from using minoxidil
Minoxidil is a safe medication and just like any other drug it has some
adverse effects. Uncommon side effects that you should report to your
doctor as soon as possible: chest pain, fast or irregular heartbeat,
palpitations,difficulty breathing, dizziness or fainting spells, skin
rash, blisters, or itching, stiff or swollen joints, sudden weight
gain, swelling of the feet or legs, unusual weakness.
Side effects that usually do not require medical attention (report to
your doctor if they continue or are bothersome):
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headache
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redness,
irritation and itching at the site of application
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unusual
hair growth, on the face, arm, and back
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Dosage:
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2%
and 5% can be used on twice daily basis 1ml in the morning and 1ml in
the evening.
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Females
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Only
2% is approved for use in females and it has to be used similarly on
twice daily basis 1ml in the morning and 1ml in the evening.
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FINASTERIDE
Finasteride belongs to the group of medicines called enzyme inhibitors.
Finasteride works at the molecular level to halt hair loss and
stimulate new hair growth. It is a medication that selectively inhibits
the activity of an enzyme that converts the "male hormone" testosterone
into a form that is active in hair follicles. Testosterone is the most
potent of the androgenic hormones. Its actions on hair follicles, skin
and prostate tissue is not direct however; these tissues are responsive
to a form of testosterone called dihydrotestosterone (DHT);
testosterone is converted to DHT by the enzyme 5-alpha-reductase.
Finasteride acts by inhibiting the action of 5-alpha-reductase and thus
inhibiting the conversion of testosterone into DHT.
Following the lead of finasteride's effectiveness in treating benign
prostate enlargement, investigators studied its use in treating MPHL.
These studies confirmed that at a dose of 1 milligram per day,
finasteride is effective in treating MPHL in some but not all men. The
5-year study showed that 9 out of 10 men treated with finasteride
either had gained or at least had not lost hair.
It is important to note that Finasteride for treatment of hair loss
should be prescribed only after examination by a doctor/ hair
restoration specialist. Finasteride is not approved the use in women,
and particularly in women who are pregnant or who become pregnant. The
drug has potential for interfering with sexual development of a fetus.
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