meta name="twitter:card" content="summary" />
The Esthetic Clinics- The Best Plastic, Cosmetic Surgery and Skin Treatment Clinics in Mumbai, India

Resources

Research Interest

In vivo intraocular distribution and safety of periocular nanoparticle carboplatin for treatment of advanced retinoblastoma in humans.

Kalita D, Shome D, Jain VG, Chadha K, Bellare JR.

PURPOSE:

To study the intraocular distribution and safety of polymethylmethacrylate nanoparticles loaded with carboplatin after posterior subtenon injection in humans.

-DESIGN:

Prospective, interventional, comparative case series.

- METHODS:

Six patients (mean age: 26.83 ± 7.5 years), scheduled to undergo planned uniocular enucleation in an institutional setting, were randomly divided into 3 groups. Each group received a 10 mg/mL posterior subtenon injection of nanoparticle carboplatin in the eye to be enucleated. Two eyes were enucleated 6, 24 and 72 hours post injection. Intravenous blood was collected during enucleation. The concentration of carboplatin reaching various intraocular tissues was determined by inductively coupled plasma atomic emission spectroscopy. The drug toxicity in the ocular tissues was assessed by histopathology and high-resolution transmission electron microscopy.

- RESULTS:

The highest level of carboplatin was detected in retinas (8.33 ± 1.69 mg/g), up to 24 hours post treatment. The intravitreal concentration continued to increase gradually until 72 hours (3.46 ± 0.26 mg/g). The choroids and lenses showed very low levels of carboplatin after 6 hours, with negligible amounts at 72 hours. No signs of tissue damage were observed on histopathology or electron microscopy. Intravenous concentration of carboplatin was undetectable in all patients.

- CONCLUSIONS:

Results may indicate an increased facilitated trans-scleral transport of nanoparticle carboplatin, with a sustained-release behavior but without any associated short-term ocular or systemic side effects in humans. The very high concentrations achieved in vitreous and retina after a single posterior subtenon injection may be clinically useful for adjunctive treatment of advanced intraocular retinoblastoma with vitreous seeds. However, further studies are needed to assess long-term toxicity and clinical efficacy.

Book Online Appointment

About Doctor
Dr Debraj Shome- Best Plastic, Cosmetic & Oculoplastic Surgeon in Mumbai, India

Dr. Debraj Shome

Best Plastic, Cosmetic & Oculoplastic Surgery in Mumbai, India

Dr. Debraj Shome is Director and Co founder of The Esthetic Clinics. He has been rated amongst the top surgeons in India by multiple agencies. The Esthetic Clinics patients include many international and national celebrities who prefer to opt for facial cosmetic surgery and facial plastic surgery in Mumbai because The Esthetic Clinics has its headquarters there.


Times Health Survey

Find us on Facebook

Photo Gallery

Dr Debraj Shome- Best Plastic, Cosmetic & Oculoplastic Surgeon in Mumbai, India
Dr Debraj Shome- Best Plastic, Cosmetic & Oculoplastic Surgeon in Mumbai, India
Dr Debraj Shome- Best Plastic, Cosmetic & Oculoplastic Surgeon in Mumbai, India
Dr Rinky Kapoor - Best Dermatologist, Skin Specialist Doctor in Mumbai, India
Dr Rinky Kapoor - Best Dermatologist, Skin Specialist Doctor in Mumbai, India
Dr Rinky Kapoor - Best Dermatologist, Skin Specialist Doctor in Mumbai, India

Our Dermatology Clinics Across Mumbai

Dermatologists in Kandivali
Dermatologists in Andheri
Dermatologists in Bandra
Dermatologists in Mahim
Dermatologists in Parel
Dermatologists in Dadar
Dermatologists in Chembur
Dermatologists in Vile Parle
Dermatologists in Khar
Dermatologists in Santacruz
Dermatologists in Goregoan
Dermatologists in Malad
Dermatologists in Jogeshwari
Dermatologists in Borivali

Latest News & Press Releases

Subscribe our Newsletter for Latest Updates