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Evaluation of Efficacy of QR678 and QR678 Neo Hair Growth Factor Formulation in the Treatment of Persistent ChemotherapyI Induced Alopecia Caused Due to Cytotoxic Chemotherapy A Prospective Pilot Stud

Abstract

Background: Cancers are one of the main reasons of morbidity and mortality glob-
ally. Chemotherapy-induced alopecia (CIA) is one of the most alarming, terrifying, and
traumatic adverse effects. A range of therapeutic measures has been suggested to
alleviate CIA, but at present, there is no accepted pharmacological therapy that can
assure prevention or management.

Aim: The aim of the present study was to evaluate the efficacy of QR 678 Neo®
therapy in the treatment of persistent chemotherapy-induced alopecia in women and
men treated with cytotoxic chemotherapy for breast and lung cancers, respectively.

Methods: A total of 8 male patients with history of lung cancer and 12 female pa-
tients with history of breast cancer in the age range of 25-60 years, with WHO clas-
sification of grade I and II persistent alopecia who had undergone chemotherapy
treatment, were selected for the study. At each visit, 1.5 mL solution of QR 678® was
injected into the scalp skin of patients. A total of 8 sessions were performed at an
interval of 3 weeks each. All the patients were evaluated with standard global pho-
tography, video microscopic assessment, and patient self-assessment questionnaire
at baseline, 6 months, and 1 year.

Results: Marked improvement was seen in the global assessment score at 6 months
(mean-8) which was maintained even after 1 year. Mean score increase in hair count
at 6 months was 12.71 which further increased at 1 year. High satisfaction score was
given by patients for slowing of hair loss (mean = 4.2) and also for overall hair growth.
For appearance and growth of hair, the mean value was 3.4 and 3.8, respectively.

Conclusion: The formulation of QR 678® and QR 678® Neo showed to be signifi-
cantly safe and efficient for chemotherapy-induced alopecia in both men and women.
Improvement in hair growth was maintained even at 1 year of follow-up. No patient
had any severe adverse effects, and injections were also easily bearable by most of
them.

 

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Dr. Debraj Shome is Director and Co founder of The Esthetic Clinics. He has been rated amongst the top surgeons in India by multiple agencies. The Esthetic Clinics patients include many international and national celebrities who prefer to opt for facial cosmetic surgery and facial plastic surgery in Mumbai because The Esthetic Clinics has its headquarters there.



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