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Carboplatin loaded polymethylmethacrylate nano-particles in an adjunctive role in retinoblastoma: an animal trial.

Shome D, Kalita D, Jain V, Sarin R, Maru GB, Bellare JR.

PURPOSE:

The purpose of the study is to compare the intra-vitreal concentrations of carboplatin, post peri-ocular injections of commercially available carboplatin (CAC) and a novel carboplatin loaded polymethylmethacrylate nanoparticulate carboplatin (NPC), in either eye, as a model system for treatment of advanced intra-ocular retinoblastoma (RB).

-DESIGN:

Experimental, comparative, animal study.

- MATERIALS AND METHODS:

Polymethylmethacrylate nanoparticles were prepared by free radical emulsion polymerization of methyl methacrylate in aqueous solution of carboplatin in the presence of surfactant sodium dodecyl sulfate and thermal initiator ammonium persulfate. 21 Sprague-Dawley rats, aged between 6 weeks and 3 months were enrolled. The right eye of each rat was injected peri-ocularly with CAC formulation (1 ml of 10 mg/ml) and the left eye with NPC (1 ml of 10 mg/ml), post-anesthesia, by an ophthalmologist trained in ocular oncology. Three rats each were euthanized on days 1, 3, 5, 7, 14, 28 and 42, post-injection and both eyes were carefully enucleated. Intra-vitreal concentrations of CAC and NPC were determined with Inductively Coupled Plasma Atomic Emission Spectroscopy. Analysis of data was done with paired t-test.

- RESULTS:

The intra-vitreal concentration of carboplatin with NPC was ~3-4 times higher than with CAC in all animals, on all the days (P < 0.05).

- CONCLUSIONS:

A higher trans-scleral permeability gradient is obtained with the novel nanoparticles than with the commercial drug, leading to sustained higher levels of carboplatin in the vitreous. Peri-ocular injection of NPC could thus have an adjuvant efficacy in the treatment for advanced clinical RB, specifically those with vitreous seeds.

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About Doctor

Dr. Debraj Shome

Facial Plastic Surgeon, Oculoplastic Surgeon
& Cosmetic Surgeon In Mumbai, India.

Dr. Debraj Shome is rated as one of the most renowned and amongst the best plastic surgeons in India. He has been rated amongst the top cosmetic surgeons in India for almost a decade now. Dr Debraj Shome's patients include many international and national celebrities who prefer to opt for plastic surgery in Mumbai because The Esthetic Clinics has its headquarters there.

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