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Efficacy of Incobotulinum toxin-A for the treatment of masseter muscle hypertrophy in Asian Indian patients: A 2-year follow-up study


Background: With the changing trends, more and more patients are opting for non-
surgical or minimally invasive options for reshaping the face. Noninvasive treat-
ments such as incobotulinumtoxinA (Xeomin Cosmetic®; Merz Pharma Canada Ltd.,

Burlington, ON, Canada) are a preferred modality for reducing the volume of the
muscle and therefore reducing the width of masseter.
Aims: To evaluate the efficacy of Xeomin treatment in long-term management of
bilateral masseter hypertrophy in Asian Indian patients.

Patients/Methods: A total of 30 patients were enrolled in the study and were in-
jected with 30 U Xeomin on each side of face, at baseline. Fifteen patients received a

second session of Xeomin injection at 12th week, and remaining 15 patients received

an additional third session, at 12th and 24th weeks post the first injection, respec-
tively. Follow-up was done at 4th-, 12th-, 24th-, and 36th-week and at first- and

second-year follow-ups.
Results: For the patients who received two injections, the maximum reduction of
26.85% was observed at 24th week, which was maintained as 20.04% reduction until
second follow-up year. The patients who received three injections exhibited very
high reduction of 43.12% of masseter volume at 36th week, which was maintained
at 38.72 % until the second follow-up year. Three sessions of Xeomin injections were
proved to be more effective in long-term maintenance of reduced masseter volume
than 2 sessions of injections.
Conclusions: Xeomin injections were found to be effective in long-term management
of bilateral masseter hypertrophy. This is the first of its kind paper, which evaluates
the long-term effects of Xeomin injections for the treatment of masseter hypertrophy.

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Dr. Debraj Shome

Dr. Debraj Shome is Director and Co founder of The Esthetic Clinics. He has been rated amongst the top surgeons in India by multiple agencies. The Esthetic Clinics patients include many international and national celebrities who prefer to opt for facial cosmetic surgery and facial plastic surgery in Mumbai because The Esthetic Clinics has its headquarters there.

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